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![]() Closing procedures for the fiscal quarter and year ended December 31, 2022, are not yet complete. The Company intends to provide a detailed operational and financial update during its fourth quarter and full-year 2022 earnings call in March 2023. The energy and enthusiasm within our company is high as we look to establish a strong launch trajectory with our novel product in this highly competitive, yet attractive market." "The commercial team is implementing our launch strategy and are committed to disciplined execution over time. "I am pleased with the early receptivity to ROLVEDON from our oncology customers in the first quarter of our launch," said Tom Riga, President and Chief Executive Officer of Spectrum Pharmaceuticals. The top three community oncology networks, representing approximately 22% of the total clinic market, have begun utilizing ROLVEDONĬash, cash equivalents and marketable securities of $75 million at on Octowith a comprehensive strategy to address community oncology, 340B and non-340B hospitalsħ0 targeted accounts purchased ROLVEDON during the launch quarter Preliminary unaudited net sales for the quarter ending Decemare expected to be approximately $10 million (NasdaqGS: SPPI), a biopharmaceutical company focused on novel and targeted oncology, today announced business highlights and preliminary ROLVEDON net sales for the quarter and year ended December 31, 2022.īusiness Highlights and Preliminary, Unaudited Financial Results Cash, cash equivalents and marketable securities of $75 million at, which is expected to extend cash runway through 2024 -īOSTON, January 31, 2023-( BUSINESS WIRE)-Spectrum Pharmaceuticals, Inc. Preliminary unaudited Q4 2022 net sales expected to be approximately $10 million. ![]() ![]() ![]() This is done by using a standard single crystal sample with known unit cell. Electron diffraction spot pattern of a sample. a single diffraction pattern (SAED or PED). For example, a vector cube axis can be called a 100, 010, or 001 vector. A shorter version of this paper has been accepted for publication in a special issue on the Structure of Nanocrystals of the Zeitschrift fuer Kristallographie, International journal for structural, physical, and chemical aspects of crystalline materials. ) Also, a single crystal creates an ordered array of spots and several randomly. equally correct, ways to index a diffraction pattern. An appeal is made to share the structural data of nanocrystals freely over the internet and infrastructure that would allow this sharing is mentioned. diffraction contrast and quantitative defect analysis in the TEM with many useful examples. Nanocrystal structure specific limitations to the application of this strategy are discussed. A.6 Indexed Single Crystal Diffraction Patterns: fcc, bcc, dc, hcp. Don’t try to do this Fourier Transform at home. It is a diffraction pattern from the very complex surface. A novel strategy for lattice-fringe fingerprinting of nanocrystals from Fourier transforms of high-resolution phase contrast transmission electron microscopy images is briefly outlined. When a laser illuminates a rough surface or passes through a region where it can scatter a little bit, the result is a speckle pattern. ![]() when either the kinematic or quasi-kinematic scattering approximations are sufficiently well satisfied. Suggestions are made on how some of these methods could be enhanced when nanocrystals and novel instrumentation are involved, i.e. A review of the existing fingerprinting methods for crystal structures by means of transmission electron microscopy which work for a single setting of the specimen goniometer is given. This paper illustrates the prospective need for structural fingerprinting methods for nanocrystals. ![]() ![]() ‘It’s important you choose the right kind of glass cleaner as printed glass requires a different cleaning product than plain door glass,’ explains Michael Coke, biomass product development manager at Stovax. To do so, wipe it with stove glass cleaner, leave for five minutes, then remove with a damp rag. To maintain the optimum view of the flames, you should clean the glass of a wood burning stove. ‘Ashes will need to be removed a couple of times a day when using smokeless fuel but as little as once a week when burning wood. You will need a good size ash pan for ease of cleaning and removal of ashes.’ 2. ‘Even a pure wood burning stove produces ash though far less than multi fuel stoves burning smokeless fuel,’ explains Declan Kingsley-Walsh, managing director at Morsø UK. Note that this is something you should do regularly during the heating season. Leave them to cool outside for a few days before disposal. ![]() ‘The ash can get into the air if you’re not careful and make a huge mess, so be sure to go slow.’īe aware that ashes may still contain small embers. ![]() ‘Carefully gather the ashes in the shovel and gently slide them into the bucket,’ explains Jen Stark, founder of Happy DIY Home. Ashes can be removed in an ash pan, then placed in a metal bucket. Alternatively, use a shovel along with a metal bucket. It’s also important to protect the floor area around the stove using an old towel or similar. It’s vital to stay safe when cleaning wood burning stoves so before you start cleaning make sure yours is completely cool. Heavy-duty floor cleaner and bristle brush.Vacuum cleaner and soft brush attachment or soft, lint-free cloth. ![]() ![]() ![]() In a 1984 issue of Heavy Metalhe wrote: “I am continually annoyed by careless references to “The Sentinel” as “the story on which 2001 is based” it bears about as much relation to the movie as an acorn to the resultant full-grown oak. Though it seems Clarke would have objected to this characterization of the relationship of story to film. Clarke and Stanley Kubrick developed the film 2001: A Space Odyssey and the novel 2001: A Space Odyssey at the same time, both based in part on Clarke’s “The Sentinel,” which was originally written for a BBC contest (it was not a finalist). Clarke’s “The Sentinel” (1948), published in Ten Story Fantasy as “Sentinel of Eternity” (1951) Hopefully, they’re all at least in range.Ģ001: A Space Odyssey (1968), based on Arthur C. ![]() Story of Your Life) here, though they are often included in similar lists.Īs a point of interest, I’ve also compared the lengths of the original short stories to the lengths of their film adaptations, and organized them from widest to least difference-but be warned that editions vary, so the page lengths listed here are from whatever book I could get my hands on (or preview online) and may not match your own version. I did my best to limit this list to films truly adapted from single short stories, excluding adaptations of groups of stories (like Julieta), adaptations of full collections, and adaptations of novellas or anything else long enough to be typically published as a standalone book (other than as a film tie-in), which means you won’t see Stand By Me (a.k.a The Body) or The Shawshank Redemption (both novellas collected in King’s Different Seasons, by the way, along with Apt Pupil and The Breathing Method-adaptation coming in 2020) or Breakfast at Tiffany’s or Arrival (a.k.a. Most of them are based on novels, or novel series, which only makes sense-there’s often a ton of material to work with-and things usually have to be cut, but when movies are based on short stories, there’s the trickier business of expansion. ![]() Spoilers ahead for those who have not yet seen Arrival.Literary adaptations have always been popular on the big screen, though every year it seems they’re more popular than ever. In fact, the hints were so well-planted that in a recent conversation, Hotte revealed that while rewatching the film, even he picked up on clues he had missed the first time around. ![]() Perhaps even more astonishing than said final-act twist-which was brainstormed by Ted Chiang in his 1998 short story “Story of Your Life,” on which Arrival is based-are the clues that production designer Patrice Vermette and set decorator Paul Hotte cleverly embedded into the design of the film to telegraph the film’s surprise revelation. If Oscars were given for mind-blowing twists, Denis Villeneuve’s beautiful, thought-provoking sci-fi film Arrival, starring Amy Adams, would win hands down this February 26. Check every day this week for another close-up look at 2017’s Oscar nominees. With voting open for this year’s Oscars, we’re taking a closer look at some of the craftspeople nominated for the year’s best films-from the people who re-created the Golden Age of Hollywood for the Coen Brothers to the makeup artist who redefined a pop culture icon. ![]() ![]() They become a coping mechanism, a figurative escape valve, and a way to regulate the negative emotions that are exacerbated by rumination. It appears that rumination leads to this type of uncontrolled behaviours. In the case of binge drinking, a longitudinal study carried out among US university students found a causal link between rumination, depression, and heavy drinking.
![]() ![]() In May 2020, a pachislot machine simply titled Pachislot Zero was announced by Yamasa Group. The story follows a girl named Maya, who is trapped in a haunted house controlled by a mysterious woman in black, and seeks to escape the woman's control. A spin-off for the Nintendo 3DS, Spirit Camera, was released in all regions in 2012. The game's service was terminated in 2011. Seventy different ghosts were available to collect, with each new ghost triggering the sending of an email to provide clues for finding the next ghost or other messages. ![]() ![]() The game involves users taking pictures of their environments and superimposing ghost images somewhere in the frame. A remaster of Fatal Frame: Mask of the Lunar Eclipse for the same platforms followed in 2023.Ī mobile title, Real Zero, was released in 2004 for FOMA and DoCoMo mobile devices. The new version was released on the Nintendo Switch, PlayStation 4, PlayStation 5, Xbox One, Xbox Series X/S, and Microsoft Windows. During Nintendo's E3 2021 Nintendo Direct, it was announced that a remaster of Fatal Frame: Maiden of Black Water would be available later in 2021. A new expanded remake for the Wii was released in Japan and Europe in 2012. For Crimson Butterfly, a "Director's Cut" for the Xbox was released in 2004 in Japan and North America, and 2005 in Europe. It featured additional story elements, gameplay refinements and a new difficulty setting. An expanded port of the original game was released for the Xbox in 2002 in Japan and 2003 in Western territories. The first two titles have received expanded re-releases. The fifth title, Fatal Frame: Maiden of Black Water, was released for the Wii U in 2014 in Japan and 2015 in North America, Europe and Australia. In 2008, Fatal Frame: Mask of the Lunar Eclipse released in Japan for the Wii, with no contemporaneous release overseas. Fatal Frame III: The Tormented likewise released for the PlayStation 2 in 2005 for Japan and North America, and 2006 in Europe. The second game, Fatal Frame II: Crimson Butterfly, was released again for PlayStation 2 in 2003 in Japan and North America, and 2004 in Europe as well as for Xbox in 2004 in North America and in 2005 in Europe. The titular first entry in the series was released on the PlayStation 2 in 2001 in Japan and 2002 in North America and Europe and on the Xbox in 2002 in North America and 2003 in Europe. Video games Main series Release timeline 2001 Koei Tecmo would later purchase Nintendo's publishing rights for multi platform re-releases of Fatal Frame: Mask of the Lunar Eclipse and Fatal Frame: Maiden of Black Water. Since the fourth game, new Fatal Frame titles have been funded and co-developed by Nintendo, resulting in new series titles since the fourth game originally only appearing on Nintendo consoles. This was due to the series' creators considering each entry to be a standalone game, with minimal connections to previous titles. Outside their international releases, the Fatal Frame games are not numbered. Multiple Japanese media adaptations have been made, including manga and a 2014 live-action feature film.Īs of 2014, the series consists of five mainline video games, not counting remakes, re-releases and spin-offs. While the sales of individual games have never been high, the series as a whole has sold over one million copies worldwide as of April 2014. The series is recognized as one of the best-known horror video game franchises, and the second game in the series, Crimson Butterfly, is considered one of the scariest horror games ever made. Later installments have refined the gameplay mechanics while also adding more complex narrative elements. Their main goal was to make the most frightening game experience possible. After being introduced to the PlayStation 2 hardware and after the success of the Silent Hill series, the pair decided to develop a horror series inspired by Shibata's own spiritual experiences and popular Japanese horror films of the time. ![]() The series was conceived by Makoto Shibata and Keisuke Kikuchi. The series draws on staple elements of Japanese horror, and is noted for its frequent use of female protagonists. Kunihiko Asou that can capture and pacify spirits. In each scenario, the characters involved in the present investigation use Camera Obscura, objects created by Dr. The series is set in 1980s Japan, with each entry focusing on a location beset by hostile supernatural events. Debuting in 2001 with the first entry in the series for the PlayStation 2, the series consists of five main entries. PlayStation 2, Microsoft Windows, Nintendo 3DS, Nintendo Switch, PlayStation 4, PlayStation 5, Wii, Wii U, Xbox, Xbox One, Xbox Series X/Sįatal Frame, titled Zero in Japan and Project Zero in Europe and Australia, is a Japanese survival horror video game series created, published and developed by Koei Tecmo (originally Tecmo). EU: Microsoft Game Studios, Nintendo, Take-Two Interactive, Ubisoft, Wanadoo. ![]() ![]() Tons of extraneous style application and markup of unwanted elements (line-breaks, crop-marks, etc). However, the HTML that Adobe exported was U G L Y. I decided editing the HTML directly would give me the most precise control over everything. I’d need to create style classes, inspect parts of the text with unique formatting, re-insert images optimized for display in the ebook environment. All of these alternate formats, based on the PDF, would need quite a bit of fine-tuning. This produced a set of files (html, css, and images) fairly similar in display quality to the Calibre conversion, the KDP conversion, and the Word copy/paste. It also included artificial line-breaks (which would interrupt reflowability).įinally, I tried exporting HTML from the PDF using Adobe Acrobat. I also attempted uploading a copy of the PDF to KDP for conversion, an although it impressively removed the crop marks and other repeating page elements, images were again partially left out (partially because some textual elements from images were preserved, like chart text, which was probably an artifact of the Adobe OCR process).Ĭopy/special-pasting directly from the PDF to Word did a decent job of preserving italics and bold text, but also preserved unwanted repeating page elements. The program produced a fairly literal conversion (including crop-marks) but with lots of strange line-breaks and no images (where did they go? I don’t know). ![]() I recently converted a book for which I only had the PDF –no InDesign files, nor Word files to port to InDesign.Įven though I knew the Calibre developer discourages conversion from PDF, I took a swing. Layout programs like InDesign offer increasingly sophisticated ebook output options that allow the user to specify reflow-friendly display instructions for elements like these (eg: don’t include page numbers in the epub output, place sidebars at the end of the section and style them differently, etc). Layout-specific elements within PDFs, like sidebars, call-outs, and anything tabular, can also befuddle converters. It’s hard for conversion programs (like Calibre and the converter built into Amazon’s KDP web-based uploader) to recognize and strip away unwanted elements like that. In the case of our most recent conversion, our PDF was fraught with various printers crop-marks, the file name, and creation date on every page. ![]() Often, PDFs carry print-specific elements that aren’t useful in the context of reflowable text, like page numbers and repeating chapter titles. Ebook conversion from PDF is possible but problematic. ![]() ![]() ![]() Fortunately the Silver and Black were once again ready to respond by being the beneficiary of bad transition defense and inattention in the half-court instead of suffering from it. They paid for it, as the visitors, who now had the hot hand from beyond the arc, erased the deficit. San Antonio recovered quickly, but then had one of those offensive droughts that have been common all season. A couple of empty possessions by the Spurs and consecutive makes by the Hawks quickly resulted in the lead shrinking to five. The only issue in the first quarter was turnovers and it unfortunately continued in the second frame. As the benches checked in, the Spurs only got more comfortable, hitting outside shots with ease and getting good rim protection from a very active Charles Bassey. Trae Young could get past Jeremy Sochan, but he couldn’t score inside and no one else could do much against a defense that was surprisingly disciplined in the half-court in the first quarter. ![]() San Antonio got a quick double-digit lead, as the Hawks struggled to find shot creation on offense. The big man was everywhere on both ends to lead the Spurs to a great first few minutes. ![]() Victor Wembanyama was questionable to suit up due to hip tightness but seemed fully healthy and ready to dominate early in the game. Trae Young took over in the second half to lead Atlanta to a 137-135 win in an entertaining game that simply slipped away late for the Silver and Black.įrom the start, it was clear the rested Spurs were going to put up a fight. Despite playing well on offense and having a standout performance from Jeremy Sochan, they couldn’t prevail against the Hawks. The Spurs have now lost 13 games in a row. ![]() ![]() ![]() Pets are not allowed in the campground or beach area of the park. Five cabins are available each sleeps six people, has electricity, and includes a fire ring and picnic table. The park also has a camp store where canoe and kayak rentals are available, as well as a public canoe and kayak launch. There are no hook-ups at any of the campsites. 24 hour showers are available on Big Island and Horse Island. The bathhouses are equipped with running water, flush toilets. Each campsite has an open fire ring, picnic table, flat areas for a tent, and a parking space. The 192 sites are wooded and many provide views of the lake. Pawtuckaway State Park Campground lines the shore of beautiful Pawtuckaway Lake. The project includes construction of new septic systems.Demolish and replace 5 toilet buildings in the Big Island and Horse Island camping areas.Construct a new recreational vehicle dump station along the park road.The Division is proposing to do the following: toilet buildings), to support existing visitors and meet the demand for camping experiences. Recreation to replace obsolete infrastructure, add new infrastructure and supporting facilities (i.e. Pawtuckaway State Park Improvement Project, 2024 Alcohol is prohibited at the Pawtuckaway State Park Beach Area ![]() A list of New Hampshire State Park swimming locations is posted here Kingston State Park and Bear Brook State Park are both approximately a half-hour from Pawtuckaway State Park. There are many opportunities for hiking, with trails leading to many special points of interest, including a mountaintop fire tower an extensive marsh where beavers, deer, and great blue herons may be seen, and a geologically unique field where large boulders called glacial erratics were deposited when glacial ice melted near the end of the Ice Age.īeach Policy: The Pawtuckaway State Park beach area often reaches capacity in the morning hours on weekends and holidays and once it reaches capacity the beach will be closed to additional visitors to ensure the safety of our visitors. The park includes a large family beach on the lake. Pawtuckaway State Park offers a variety of landscapes, with something to do and see for everyone. ![]() |
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